The team helps Deputy Director Sam Cullen’s daughter, Amy, when she contracts a rare form of lung cancer after receiving a bone graft. Booth and Brennan learn she is not the only victim with this rare form of cancer.

Brennan takes a vacation down to New Orleans to help identify victims of Hurricane Katrina. While at her hotel, she wakes up the next morning bloody and beaten, with no memory of what happened. Booth comes down to try and help her figure out what happened. When the local medical examiner is found murdered, Brennan becomes the suspect. Their investigation leads them into the world of voodoo.